Dr. Araks Martirosyan
ABI Remote Supervisor
Dr. Araks Martirosyan is a postdoctoral researcher in the Laboratory of Glia Biology at the VIB-KU Leuven Center for Brain and Disease Research (Belgium). After Finishing her B.Sc. in the Faculty of Physics at Yerevan State University (Armenia) and M.Sc. in Applied Physics at Cergy-Pontoise University (France), she became interested in the application of Statistical Physics to Biology and chose Computational Biology as her future research direction.
Dr. Martirosyan received her Ph.D. from the Sapienza University of Rome (Italy) in 2016. Shortly after she joined the VIB-KU Leuven Laboratory of Glia Biology headed by Prof. Matthew Holt, where she investigates the molecular heterogeneity of astrocytes – a major non-neuronal cell type in the brain, whose therapeutic potential is largely overlooked. Combining cutting-edge single-cell RNA-seq and novel spatial transcriptomics technologies, Dr. Martirosyan was amongst the first to describe unique astrocyte subtypes in the brain. The goal of her current work is to understand how these subtypes respond to injury and/or disease.
Araks Martirosyan supervised ABI student Arabo Apresyan on a project analyzing developmental neuroscience and single-cell transcriptomics.
Research Interests
- Developmental Neuroscience
- Single-cell transcriptomics
- Astrocyte subtypes in the brain
Publications
Pestana, F., Edwards-Faret, G., Belgard, T.G., Martirosyan, A., Holt, M.G. (2020). No Longer Underappreciated: The Emerging Concept of Astrocyte Heterogeneity in Neuroscience. Brain Sciences, 10 (3), Art.No. ARTN 168. doi: https://doi.org/10.3390/brainsci10030168
Martirosyan, A., Del Giudice, M., Bena, C.E., Pagnani, A., Bosia, C., De Martino, A. (2019). Kinetic Modelling of Competition and Depletion of Shared miRNAs by Competing Endogenous RNAs. Computational Biology of Non-Coding RNA: Methods and Protocols, 1912, 367-409. doi: 10.1007/978-1-4939-8982-9_15
Martirosyan, A., Marsili, M., De Martino, A. (2017). Translating ceRNA Susceptibilities into Correlation Functions. Biophysical Journal, 113 (1), 206-213. doi: https://doi.org/10.1016/j.bpj.2017.05.042
Martirosyan A, De Martino A, Pagnani A, Marinari E. (2017) ceRNA crosstalk stabilizes protein expression and affects the correlation pattern of interacting proteins. Scientific Reports 7: 43673. doi: https://doi.org/10.1038/srep43673
Martirosyan A, Figliuzzi M, Marinari E, De Martino A. (2016) Probing the Limits to MicroRNA-Mediated Control of Gene Expression. PLOS Computational Biology 12: e1004715. doi: 10.1371/journal.pcbi.1004715
Martirosyan A, Paulevé L, Poignard C, Régnier M, Steyaert J-M, Schwartz L. (2012) A Dynamical Model for the Transmembrane Potential Regulation by pH. Preprint: hal-00769446. doi: https://hal.archives-ouvertes.fr/hal-00769446
Batiuk, M.Y., Martirosyan, A., Wahis, J., de Vin, F., Marneffe, C., Kußerow, C., Koeppen, J., Viana, J.F., Oliveira, J.F., Voet, T., Ponting, C.P., Belgard, T.G., Holt, M. (contr.) (2019). Characterization of unique astrocyte subpopulations points to specialization in local CNS function. Nature Communications. doi: https://doi.org/10.1038/s41467-019-14198-8
Martirosyan A, Saakian DB. (2011) Exact results in the large system size limit for the dynamics of the chemical master equation, a one-dimensional chain of equations. Physical Review E 84: 021122. doi: 10.1103/PhysRevE.84.021122
Bayraktar, O.A., Bartels, T., Holmqvist, S., Kleshchevnikov, V., Martirosyan, A., … G., Rowitch, D.H., Holt, M. (contr.) (2019). Single-cell in situ transcriptomic map of astrocyte cortical layer diversity.Nature Neuroscience. doi: http://dx.doi.org/10.1101/432104