Arsen Arakelyan

Dr. Arsen Arakelyan

ABI Executive board member, Ph.D. Dr.

Dr. Arsen Arakelyan, Ph.D., is the director of the Institute of Molecular Biology (IMB) and the director of the Institute of Biomedicine and Pharmacy of the Russian Armenian University (RAU). Dr. Arakelyan was the first one to establish the research direction of genome bioinformatics in Armenia, opening the Bioinformatics Group at the Institute of Molecular Biology in 2011. The few specialists currently conducting research in this field in Armenia have all gained their experience in this group. Now, Arsen is actively engaged in the establishment of ABI to create the human capital in the field at a much broader scope and faster pace.

Dr. Arakelyan is an award-winning scientist with 23+ years of experience in wet-lab molecular biology/genetics and dry lab bioinformatics, pathway analysis, and systems biology. He is leading the national COVID-19 test production in Armenia. At the same time, Dr. Arakelyan is a professor at the Russian-Armenian University and an adjunct lecturer at the American University of Armenia (AUA). He has 104 publications and 2 filed patents.

Research Interests

  • Genomics and transcriptomics
  • High-throughput data analysis
  • Pathway signal flow analysis
  • Mining the next generation sequencing data for systems biology research
  • Telomere bioinformatics

Publications

Arakelyan A, Melkonyan A, Hakobyan S, Boyarskih U, Simonyan A, Nersisyan L, Nikoghosyan M, Filipenko M, Binder H. Transcriptome Patterns of BRCA1– and BRCA2– Mutated Breast and Ovarian Cancers. Int J Mol Sci. 2021 Jan 28;22(3):1266. doi: 10.3390/ijms22031266. PMID: 33525353; PMCID: PMC7865215. doi: https://doi.org/10.3390/ijms22031266

Nersisyan L, Simonyan A, Binder H, Arakelyan A. Telomere Maintenance Pathway Activity Analysis Enables Tissue- and Gene-Level Inferences. Front Genet. 2021 Apr 7;12:662464. doi: 10.3389/fgene.2021.662464. PMID: 33897770; PMCID: PMC8058386. doi: https://doi.org/10.3389/fgene.2021.662464

Avetyan D, Chavushyan A, Ghazaryan H, Melkonyan A, Stepanyan A, Zakharyan R, Hayrapetyan V, Atshemyan S, Khachatryan G, Sirunyan T, Davitavyan S, Martirosyan G, Melik-Andreasyan G, Sargsyan S, Ghazazyan A, Aleksanyan N, Yin X, Arakelyan A. SARS-CoV-2 detection by extraction-free qRT-PCR for massive and rapid COVID-19 diagnosis during a pandemic in Armenia. J Virol Methods. 2021 Sep;295:114199. doi: 10.1016/j.jviromet.2021.114199. Epub 2021 Jun 4. PMID: 34091213; PMCID: PMC8175123. doi: https://doi.org/10.1016/j.jviromet.2021.114199

Nersisyan L, Nikoghosyan M; Genome of the Netherlands consortium, Arakelyan A. WGS-based telomere length analysis in Dutch family trios implicates stronger maternal inheritance and a role for RRM1 gene. Sci Rep. 2019 Dec 10;9(1):18758. doi: 10.1038/s41598-019-55109-7. PMID: 31822713; PMCID: PMC6904582. doi: https://doi.org/10.1038/s41598-019-55109-7

Nikoghosyan M, Hakobyan S, Hovhannisyan A, Loeffler-Wirth H, Binder H, Arakelyan A. Population Levels Assessment of the Distribution of Disease-Associated Variants With Emphasis on Armenians – A Machine Learning Approach. Front Genet. 2019 Apr 26;10:394. doi: 10.3389/fgene.2019.00394. PMID: 31105750; PMCID: PMC6498285. doi: https://doi.org/10.3389/fgene.2019.00394

Hakobyan A., Nersisyan L., Arakelyan A.. Quantitative trait association study for mean telomere length in the South Asian Genomes. Bioinformatics 2016, 32(11):1697-700. doi: https://doi.org/10.1093/bioinformatics/btw027