The lab’s central interest is the development of algorithms and software solutions for genomics research. The team is currently focused on
- microbiome research,
- mRNA degradome analysis,
- genetic engineering applications,
- single-cell transcriptomics,
- cell-free DNA,
- telomere biology.
Team
Nelly Vardazaryan
MSc Student
Tatevik Jalatyan
MSc Student
Jakub Wudarski
Specially Appointed Assistant Professor at National Institute for Basic Biology Japan
Daria Laricheva
BSc Student
Valeri Vardanyan
Cosmologist and astrophysicist, Kavli fellow at IPMU
MSc Student
BSc Student
BSc Student
Relevant Publications
Huch S., Nersisyan L., Ropat M., Barrett D., Wu M., Wang J., D. Valeriano V., Vardazaryan N., Huerta-Cepas J., Wei W., Du J., M. Steinmetz L., Engstrand L., Pelechano V. (2023). Atlas of mRNA translation and decay for bacteria. Nature Microbiology. 10.1038/s41564-023-01393-z
S Huch, L Nersisyan, M Ropat, D Barret, J Wang, J Huerta-Cepas, W Wei, L M Steinmetz, L Engstand, V Pelechano. RNA degradation analysis reveals ribosome dynamics in complex microbiome samples. medRxiv. 2021.04.08. Doi: 10.1101/2021.04.08.439066
L Nersisyan, M Ropat, V Pelechano. Improved computational analysis of ribosome dynamics from 5′P degradome data using fivepseq. NAR Genomics and Bioinformatics. 2020. Volume 2, Issue 4, doi: https://doi.org/10.1093/nargab/lqaa099
L Nersisyan, M Nikoghosyan, The Genome if the Netherlands consortium & A Arakelyan. WGS-based telomere length analysis in Dutch family trios implicates stronger maternal inheritance and a role for RRM1 gene. Scientific Reports. 2019. Volume 9, Article number: 18758
L Nersisyan, L Hopp, H Loeffler-Wirth, J Galle, M Loeffler, A Arakelyan, H Binder. Telomere Length Maintenance and Its Transcriptional Regulation in Lynch Syndrome and Sporadic Colorectal Carcinoma. Frontiers in oncology. 2019. Volume 9. doi: https://doi.org/10.3389/fonc.2019.01172
L Nersisyan, G Johnson, M Riel-Mehan, A R Pico, A Arakelyan. PSFC: a Pathway Signal Flow Calculator App for Cytoscape. F1000Research. 2015. Version 2. 4: 480. doi: 10.12688/f1000research.6706.2
L Nersisyan, A Arakelyan. Computel: Computation of Mean Telomere Length from Whole-Genome Next-Generation Sequencing Data. PLoS one. 2015. Volume 10, 4. doi: https://doi.org/10.1371/journal.pone.0125201
L Nersisyan, R Samsonyan, A Arakelyan. CyKEGGParser: tailoring KEGG pathways to fit into systems biology analysis workflows. F1000Research. 2014. Version 2. 3: 145. doi: 10.12688/f1000research.4410.2
Funding
Ongoing Projects
Modeling the effects of cigarette and e-cigarette smoke on oral and gut microbiome
Faculty research grant from EIF and PMI Science
PI: Lilit Nersisyan
Year: 2022
Open Positions
Open positions up to internships. For more information email the lab supervisor Dr. Lilit Nersisyan.