The lab’s central interest is the development of algorithms and software solutions for genomics research. The team is currently focused on
- microbiome research,
- mRNA degradome analysis,
- genetic engineering applications,
- single-cell transcriptomics,
- cell-free DNA,
- telomere biology.
Team
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Nelly Vardazaryan
MSc Student
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Tatevik Jalatyan
MSc Student
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Jakub Wudarski
Specially Appointed Assistant Professor at National Institute for Basic Biology Japan
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Daria Laricheva
BSc Student
![](https://abi.am/wp-content/uploads/1639794107561-edited.jpeg)
Valeri Vardanyan
Cosmologist and astrophysicist, Kavli fellow at IPMU
![](https://abi.am/wp-content/uploads/photo-08-2.png)
MSc Student
![](https://abi.am/wp-content/uploads/IMG_9327-974x1024.jpg)
BSc Student
![](https://abi.am/wp-content/uploads/students-17.png)
MSc Student
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MSc Student
Relevant Publications
Huch S., Nersisyan L., Ropat M., Barrett D., Wu M., Wang J., D. Valeriano V., Vardazaryan N., Huerta-Cepas J., Wei W., Du J., M. Steinmetz L., Engstrand L., Pelechano V. (2023). Atlas of mRNA translation and decay for bacteria. Nature Microbiology. 10.1038/s41564-023-01393-z
S Huch, L Nersisyan, M Ropat, D Barret, J Wang, J Huerta-Cepas, W Wei, L M Steinmetz, L Engstand, V Pelechano. RNA degradation analysis reveals ribosome dynamics in complex microbiome samples. medRxiv. 2021.04.08. Doi: 10.1101/2021.04.08.439066
L Nersisyan, M Ropat, V Pelechano. Improved computational analysis of ribosome dynamics from 5′P degradome data using fivepseq. NAR Genomics and Bioinformatics. 2020. Volume 2, Issue 4, doi: https://doi.org/10.1093/nargab/lqaa099
L Nersisyan, M Nikoghosyan, The Genome if the Netherlands consortium & A Arakelyan. WGS-based telomere length analysis in Dutch family trios implicates stronger maternal inheritance and a role for RRM1 gene. Scientific Reports. 2019. Volume 9, Article number: 18758
L Nersisyan, L Hopp, H Loeffler-Wirth, J Galle, M Loeffler, A Arakelyan, H Binder. Telomere Length Maintenance and Its Transcriptional Regulation in Lynch Syndrome and Sporadic Colorectal Carcinoma. Frontiers in oncology. 2019. Volume 9. doi: https://doi.org/10.3389/fonc.2019.01172
L Nersisyan, G Johnson, M Riel-Mehan, A R Pico, A Arakelyan. PSFC: a Pathway Signal Flow Calculator App for Cytoscape. F1000Research. 2015. Version 2. 4: 480. doi: 10.12688/f1000research.6706.2
L Nersisyan, A Arakelyan. Computel: Computation of Mean Telomere Length from Whole-Genome Next-Generation Sequencing Data. PLoS one. 2015. Volume 10, 4. doi: https://doi.org/10.1371/journal.pone.0125201
L Nersisyan, R Samsonyan, A Arakelyan. CyKEGGParser: tailoring KEGG pathways to fit into systems biology analysis workflows. F1000Research. 2014. Version 2. 3: 145. doi: 10.12688/f1000research.4410.2
Funding
Ongoing Projects
Modeling the effects of cigarette and e-cigarette smoke on oral and gut microbiome
Faculty research grant from EIF and PMI Science
PI: Lilit Nersisyan
Year: 2022
Open Positions
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We are seeking highly motivated and talented individuals with a preferential background in computer & data science to join our research team at ABI Nersisyan lab as Bioinformatics Interns.
Open positions up to internships. For more information email the lab supervisor Dr. Lilit Nersisyan.