We are pleased to announce that the research paper “Temporal Changes of Gene Expression in Health, Schizophrenia, Bipolar Disorder, and Major Depressive Disorder” has been published in Nature Schizophrenia. This study, conducted by Arakelyan et al., utilized advanced bioinformatics and machine learning to analyze post-mortem prefrontal cortex samples, exploring gene expression dynamics in schizophrenia, bipolar disorder, and major depressive disorder patients across different ages.
The research uncovered critical time-dependent changes in gene modules related to neurodevelopment, plasticity, and immune responses, linked to genetic loci that influence gene expression. These findings shed light on how genetic variations contribute to the onset and progression of these psychiatric disorders, offering promising avenues for early diagnosis and intervention. Congratulations to Arsen Arakelyan from IMB and ABI, Hans Binder, Alexey Kurnosov, Susie Avagyan, and all co-authors on this significant achievement.