Binder Lab

The lab’s central interests are describing and understanding genomic regulation, its diversity, and its impact on health and disease. We address a wide range of issues such as

  • Mechanisms of cancer heterogeneity, treatment resistance, and immune therapy at the single-cell level
  • Genome atlas of vine accessions in the Caucasus
  • Evolution of Coronavirus genomes
  • Molecular mechanisms of human aging

Under a methodical perspective, we are developing and applying methods for multi-omics analytics (transcriptomics, epi-/genetics, and others), phenotypic associations, feature extraction, and clustering with a strong focus on visualization. 

  • Machine learning of genomic diversity and function prediction
  • Single-cell omics analysis: from pseudotime to cell-cell interactions
  • Pathway analysis

In general, we aim to extract information about the functioning of life hidden in large and complex data with the help of computers to improve healthcare and to save biodiversity. 


Lab Leader

Research Students

Vardan Saroyan

Vardan Saroyan

Hripsime Gasoyan

Susanna Avagyan

Uni-leipzig Mentors

Maria Schmidt

University of Leipzig
Ph.D. Student

Henry Loffler-Wirth

University of Leipzig
Ph.D. Student

Lena S. Mortensen

University of Leipzig
MSc Student

ABI Mentors

Maria Nikoghosyan

Institute of Molecular Biology NAS RA
Ph.D. Student

Siras Hakobyan

Institute of Molecular Biology NAS RA
Ph.D. Student


The Evolving Faces of the SARS-CoV-2 Genome. M Schmidt, M Arshad, SH Bernhart, S Hakobyan, A Arakelyan, H Loeffler-Wirth & H Binder. Viruses 2021, 13(9), 1764. DOI:

Deciphering the Transcriptomic Heterogeneity of Duodenal Coeliac Disease Biopsies. J Wolf, E Willscher, H Loeffler-Wirth, M Schmidt … H Binder. Int. J. Mol. Sci. 2021, 22(5), 2551. DOI:

oposSOM-Browser: an interactive tool to explore omics data landscapes in health science. H Loeffler-Wirth, J Reikowski, S Hakobyan, J Wagner & H Binder.  BMC Bioinformatics 2021465 (2020). DOI:

Developmental scRNAseq Trajectories in Gene-and Cell-State Space—The Flatworm Example. M Schmidt, H Loeffler-Wirth & H Binder. Genes 2020, 11(10), 1214. DOI:

Covid-19 transmission trajectories–monitoring the pandemic in the worldwide context. H Loeffler-Wirth, M Schmidt & H Binder. Viruses 2020, 12(7), 777. DOI:

SOMmelier—Intuitive Visualization of the Topology of Grapevine Genome Landscapes Using Artificial Neural Networks. M Nikoghosyan, M Schmidt, K Margaryan, H Loeffler-Wirth, A Arakelyan & H Binder. Genes 2020, 11(7), 817. DOI:

Covid‐19 trajectories – Monitoring pandemic in the worldwide context. H Loeffler-Wirth, M Schmidt & H Binder. medRxiv, 2020.06.04.20120725. DOI:

Transcriptome-guided drug repositioning. A Arakelyan, L Nersisyan, M Nikoghosyan, S Hakobyan, A Simonyan, L Hopp, H Loeffler-Wirth & H Binder. Pharmaceutics 2019, 11(12), 677. DOI:

A modular transcriptome map of mature B cell lymphomas. H Loeffler-Wirth, M Kreuz, L Hopp, et al. Genome Med 11, 27 (2019). DOI:

DNA methylation, transcriptome, and genetic copy number signatures of diffuse cerebral WHO grade II/III gliomas resolve cancer heterogeneity and development. H Binder, E Willscher, H Loeffler-Wirth, et al. acta neuropathol commun 7, 59 (2019). DOI:

Telomere length maintenance and its transcriptional regulation in Lynch syndrome and sporadic colorectal carcinoma. L Nersisyan, L Hopp, H Loeffler-Wirth … A Arakelyan & H Binder. Front. Oncol., 05.11.2019. DOI:

Population levels assessment of the distribution of disease-associated variants with emphasis on Armenians–a machine learning approach. M Nikoghosyan, S Hakobyan … H Loeffler-Wirth, H Binder & A Arakelyan. Front. Genet., 26.4.2019. DOI:

Open Positions

Open positions up to internships. For more information email the lab supervisor Hans Binder.