Binder Lab

The lab’s central interests are describing and understanding genomic regulation, its diversity, and its impact on health and disease. We address a wide range of issues such as

• Mechanisms of cancer heterogeneity, treatment resistance, and immune therapy at the single-cell level
• Genome atlas of vine accessions in the Caucasus
• Evolution of Coronavirus genomes
• Molecular mechanisms of human aging

Under a methodical perspective, we are developing and applying methods for multi-omics analytics (transcriptomics, epi-/genetics, and others), phenotypic associations, feature extraction, and clustering with a strong focus on visualization. 

• Machine learning of genomic diversity and function prediction
• Single-cell omics analysis: from pseudotime to cell-cell interactions
• Pathway analysis

In general, we aim to extract information about the functioning of life hidden in large and complex data with the help of computers to improve healthcare and to save biodiversity. 

People

Lab Leader

Research Students

Uni-leipzig Mentors

ABI Mentors

Publications

The Evolving Faces of the SARS-CoV-2 Genome. M Schmidt, M Arshad, SH Bernhart, S Hakobyan, A Arakelyan, H Loeffler-Wirth & H Binder. Viruses 2021, 13(9), 1764. DOI: https://doi.org/10.3390/v13091764

Deciphering the Transcriptomic Heterogeneity of Duodenal Coeliac Disease Biopsies. J Wolf, E Willscher, H Loeffler-Wirth, M Schmidt … H Binder. Int. J. Mol. Sci. 2021, 22(5), 2551. DOI: https://doi.org/10.3390/ijms22052551

oposSOM-Browser: an interactive tool to explore omics data landscapes in health science. H Loeffler-Wirth, J Reikowski, S Hakobyan, J Wagner & H Binder.  BMC Bioinformatics 2021, 465 (2020). DOI: https://doi.org/10.1186/s12859-020-03806-w

Developmental scRNAseq Trajectories in Gene-and Cell-State Space—The Flatworm Example. M Schmidt, H Loeffler-Wirth & H Binder. Genes 2020, 11(10), 1214. DOI: https://doi.org/10.3390/genes11101214

Covid-19 transmission trajectories–monitoring the pandemic in the worldwide context. H Loeffler-Wirth, M Schmidt & H Binder. Viruses 2020, 12(7), 777. DOI: https://doi.org/10.3390/v12070777

SOMmelier—Intuitive Visualization of the Topology of Grapevine Genome Landscapes Using Artificial Neural Networks. M Nikoghosyan, M Schmidt, K Margaryan, H Loeffler-Wirth, A Arakelyan & H Binder. Genes 2020, 11(7), 817. DOI: https://doi.org/10.3390/genes11070817

Covid‐19 trajectories – Monitoring pandemic in the worldwide context. H Loeffler-Wirth, M Schmidt & H Binder. medRxiv, 2020.06.04.20120725. DOI: https://doi.org/10.1101/2020.06.04.20120725

Transcriptome-guided drug repositioning. A Arakelyan, L Nersisyan, M Nikoghosyan, S Hakobyan, A Simonyan, L Hopp, H Loeffler-Wirth & H Binder. Pharmaceutics 2019, 11(12), 677. DOI: https://doi.org/10.3390/pharmaceutics11120677

A modular transcriptome map of mature B cell lymphomas. H Loeffler-Wirth, M Kreuz, L Hopp, et al. Genome Med 11, 27 (2019). DOI: https://doi.org/10.1186/s13073-019-0637-7

DNA methylation, transcriptome, and genetic copy number signatures of diffuse cerebral WHO grade II/III gliomas resolve cancer heterogeneity and development. H Binder, E Willscher, H Loeffler-Wirth, et al. acta neuropathol commun 7, 59 (2019). DOI: https://doi.org/10.1186/s40478-019-0704-8

Telomere length maintenance and its transcriptional regulation in Lynch syndrome and sporadic colorectal carcinoma. L Nersisyan, L Hopp, H Loeffler-Wirth … A Arakelyan & H Binder. Front. Oncol., 05.11.2019. DOI: https://doi.org/10.3389/fonc.2019.01172

Population levels assessment of the distribution of disease-associated variants with emphasis on Armenians–a machine learning approach. M Nikoghosyan, S Hakobyan … H Loeffler-Wirth, H Binder & A Arakelyan. Front. Genet., 26.4.2019. DOI: https://doi.org/10.3389/fgene.2019.00394

Open Positions

Open positions up to internships. For more information email the lab supervisor Hans Binder.