Binder Lab

The lab’s central interests are describing and understanding genomic regulation, its diversity, and its impact on health and disease. We address a wide range of issues such as

• Mechanisms of cancer heterogeneity, treatment resistance, and immune therapy at the single-cell level
• Genome atlas of vine accessions in the Caucasus
• Evolution of Coronavirus genomes
• Molecular mechanisms of human aging

Under a methodical perspective, we are developing and applying methods for multi-omics analytics (transcriptomics, epi-/genetics, and others), phenotypic associations, feature extraction, and clustering with a strong focus on visualization. 

• Machine learning of genomic diversity and function prediction
• Single-cell omics analysis: from pseudotime to cell-cell interactions
• Pathway analysis

In general, we aim to extract information about the functioning of life hidden in large and complex data with the help of computers to improve healthcare and to save biodiversity. 

People

Lab Leader

Research Students

Uni-leipzig Mentors

ABI Mentors

Lab Publications

Loeffler-Wirth H, Rade M, Arakelyan A, Kreuz M, Loeffler M, Koehl U, et al. Transcriptional states of CAR-T infusion relate to neurotoxicity – lessons from high-resolution single-cell SOM expression portraying. Front Immunol. 2022;13:5395. doi: https://doi.org/10.3389/fimmu.2022.994885

Binder H, Schmidt M, Hopp L, Davitavyan S, Arakelyan A, Loeffler-Wirth H. Integrated Multi-Omics Maps of Lower-Grade Gliomas. Cancers 2022, Vol 14, Page 2797. 2022;14: 2797. doi: https://doi.org/10.3390/cancers14112797

M Schmidt, M Arshad, SH Bernhart, S Hakobyan, A Arakelyan, H Loeffler-Wirth & H Binder. The Evolving Faces of the SARS-CoV-2 Genome. Viruses 2021, 13(9), 1764. doi: https://doi.org/10.3390/v13091764

H Loeffler-Wirth, J Reikowski, S Hakobyan, J Wagner & H Binder. oposSOM-Browser: an interactive tool to explore omics data landscapes in health science  BMC Bioinformatics 2021, 465 (2020). doi: https://doi.org/10.1186/s12859-020-03806-w

M Nikoghosyan, M Schmidt, K Margaryan, H Loeffler-Wirth, A Arakelyan & H Binder. SOMmelier—Intuitive Visualization of the Topology of Grapevine Genome Landscapes Using Artificial Neural Networks. Genes 2020, 11(7), 817. doi: https://doi.org/10.3390/genes11070817

A Arakelyan, L Nersisyan, M Nikoghosyan, S Hakobyan, A Simonyan, L Hopp, H Loeffler-Wirth & H Binder. Transcriptome-guided drug repositioning. Pharmaceutics 2019, 11(12), 677. doi: https://doi.org/10.3390/pharmaceutics11120677

L Nersisyan, L Hopp, H Loeffler-Wirth … A Arakelyan & H Binder. Telomere length maintenance and its transcriptional regulation in Lynch syndrome and sporadic colorectal carcinoma. Front. Oncol., 05.11.2019. doi: https://doi.org/10.3389/fonc.2019.01172

M Nikoghosyan, S Hakobyan … H Loeffler-Wirth, H Binder & A Arakelyan. Population levels assessment of the distribution of disease-associated variants with emphasis on Armenians–a machine learning approach. Front. Genet., 26.4.2019. doi: https://doi.org/10.3389/fgene.2019.00394

Previous Publications of Hans Binder

J Wolf, E Willscher, H Loeffler-Wirth, M Schmidt … H Binder. Deciphering the Transcriptomic Heterogeneity of Duodenal Coeliac Disease Biopsies. Int. J. Mol. Sci. 2021, 22(5), 2551. doi: https://doi.org/10.3390/ijms22052551

M Schmidt, H Loeffler-Wirth & H Binder. Developmental scRNAseq Trajectories in Gene-and Cell-State Space—The Flatworm Example. Genes 2020, 11(10), 1214. doi: https://doi.org/10.3390/genes11101214

H Loeffler-Wirth, M Schmidt & H Binder.Covid-19 transmission trajectories–monitoring the pandemic in the worldwide context. Viruses 2020, 12(7), 777. doi: https://doi.org/10.3390/v1207077

H Loeffler-Wirth, M Schmidt & H Binder. Covid‐19 trajectories – Monitoring pandemic in the worldwide context. Viruses, 2020, 12(7), 777;  doi: https://doi.org/10.1101/2020.06.04.20120725

H Loeffler-Wirth, M Kreuz, L Hopp, et al. A modular transcriptome map of mature B cell lymphomas. Genome Med 11, 27 (2019). doi: https://doi.org/10.1186/s13073-019-0637-7

H Binder, E Willscher, H Loeffler-Wirth, et al. DNA methylation, transcriptome, and genetic copy number signatures of diffuse cerebral WHO grade II/III gliomas resolve cancer heterogeneity and development. acta neuropathol commun 7, 59 (2019). doi: https://doi.org/10.1186/s40478-019-0704-8

Open Positions

Open positions up to internships. For more information email the lab supervisor Hans Binder.